It is important for male friends to improve their sperm quality if they want a quality baby in the process of preparing for pregnancy; however, some male friends need to be treated through drugs and surgery in order to achieve the purpose of improving semen quality due to their own disease problems. 1. Abuse of drugs is dangerous, fathers-to-be should read more drug instructions Some drugs may affect the quality of male semen and need to be applied under the guidance of a doctor, these drugs are mainly: hormones, such as high-dose glucocorticoids, androgens, anti-androgen drugs, progestins, estrogens, LHRH (GnRH) agonists or antagonists, anabolic steroid hormones (abused by athletes and some young people in the hope of increase muscle strength), etc. These hormones can affect the quality of male semen, but these impairments are usually reversible. Drugs used to treat hypertension tend to cause erectile dysfunction, especially beta-blockers and thiazides, but most do not affect reproductive function; however, a few may affect fertility. Amphiregulin, which can antagonize androgenic effects in some tissues and impair semen quality. Calcium channel blockers can also cause reversible impairment of sperm function. 5a reductase inhibitor finasteride, when used for prostate enlargement (5 mg/day), can cause a decrease in semen volume, but no impairment in semen quality was found when used for alopecia (1 mg/day). Cimetidine, which competitively inhibits the action of androgens at the receptor level. Colchicine, which may cause direct toxicity to spermatogenesis. The immunosuppressant cyclosporine A can impair fertility in rodents, but studies are lacking on whether it impairs fertility in humans. 2. There are times when a simple procedure can improve sperm quality exponentially! (1) Varicocele, a disease that is caused by obstruction of venous reflux within the spermatic cord, whereupon the spermatic veins begin to tortuously expand, which eventually leads to an increase in temperature within the scrotum, destroying the environment in which sperm reside and causing a decrease in sperm quality and testicular function. Most sperm have reduced motility in this overheated environment and do not have the stamina to complete the arduous marathon task of finding an egg. Varicocele is currently considered to be the cause of male infertility most in need of surgical correction. However, there are many methods of surgical treatment, and the most commonly performed are traditional open surgery, laparoscopic surgery and microsurgical approaches. Most foreign and domestic studies have concluded that microsurgery is the most suitable for infertility and can achieve the best results, just like the difference between inverter and fixed-frequency air conditioning, which can make sperm more comfortable. (2) Is azoospermia really an incurable disease like many cancers? The actual fact is that there is no effective treatment for azoospermia, but we, the public regular hospitals, can at least tell the patients that they don’t need to continue treatment. This can at least reduce the unnecessary pain and burden on the patient. However, with the rapid development of assisted reproductive technology in recent years, there have been many technological breakthroughs in the treatment of azoospermia in male medicine. For patients with obstructive azoospermia, surgical treatment is now completely curable. The so-called obstructive azoospermia means that the testicular sperm production function is basically normal, but due to various reasons, the sperm discharge channel is blocked. In fact, this surgical technique was available a long time ago, but due to the limitations of the surgical technique at that time, the success rate of the operation was very low, but in recent years, due to the rapid development of microsurgery for male infertility, the success rate of this surgical technique has increased to more than 70%. (3) Even for non-obstructive azoospermia patients, the success rate has increased to 70%. (3) Even for patients with non-obstructive azoospermia, sperm may not be retrieved by testicular puncture biopsy because of severely impaired testicular function, but some focal normal spermatogenic tissues may still exist in the testes, so that sperm can be searched for in the testes under a high-definition surgical microscope through microscopic sperm retrieval technology, greatly increasing the possibility of finding sperm and the amount of sperm collected, allowing these patients to This greatly increases the possibility of finding sperm and the amount of sperm collected, allowing these patients to still find sperm through microscopic sperm retrieval techniques and do IVF to fulfill their dream of becoming a father.