Nodular lesions are larger and deeper than macules and papules, mostly invading deeper down into the dermis and reaching the subcutaneous tissue in severe cases. The surface is semicircular and smooth. The surface of inflammatory nodules is red, painful and angular, with a diameter of 0.5 to 5 cm. late nodules often break down, such as late syphilis nodular lesions, skin tuberculosis nodules are ulcerated and scarred. The nodules have deeper histopathological changes mostly in the deep dermis and can invade the subcutaneous fat layer, so they can be accompanied by lipid membrane and vascular type changes. The emetic has a slight pathological change in the superficial dermis, which differs from the spotted rash and papule pathological changes in the epidermis and superficial dermis. Depending on the etiology, nodules can be limited, asymmetrical, and few in number; they can also be systemic, symmetrical, and few or sparse in number. Nodular dermatoses generally have mild acute systemic symptoms, slow onset and relatively long course, such as cutaneous tuberculosis, syphilis, and erythema nodosum chronic migrans. Therefore, they are clinically different from maculopapular and papular skin diseases. Nodules are classified as inflammatory and non-inflammatory. What are the preventive methods of implantation nodules? 1.Make a good habit of life, do not smoke. 2, maintain a good state of mind, stable emotions, have a healthy diet, usually eat more fruits and vegetables, etc., to improve self-immunity. 3.People who must work at heavy fumes, try to protect themselves, such as wearing a mask, going out regularly to get some fresh air, and having at least one check-up every year, etc. 4.Stay away from smoke, alcohol, drugs, radiation, pesticides, noise, volatile harmful gases, toxic and harmful heavy metals, etc. 5.Strengthen nutrition and strengthen physical fitness. 6.Prevent and control infections and improve your immune function. 7.Avoid wind, cold and dampness, avoid excessive tiredness, avoid smoking and alcohol, avoid eating spicy food. 8.Early diagnosis, understanding the infection, good clinical observation, early detection of damage to various systems, early treatment, and major control of infection. The prognosis of the disease is good, and some asymptomatic patients are not given treatment and no lesion progression is found during the follow-up. Patients with severe symptoms or lesion progression can be treated with glucocorticoids, which have a better outcome. For those with disease progression during hormone therapy or recurrence after hormone therapy, or those with intolerable adverse reactions during hormone therapy, immunosuppressive therapy, such as cyclophosphamide and nitrogen mustard phenylbutyrate, can be added, but there are few relevant reports.