Surgical detoxification is a type of targeted destruction based on modern physiological techniques and cellular localization. It uses remote sensing micropositioning and computer control to determine the best surgical “target” for addiction by analyzing the electrical signals in brain cells and supplementing them with advanced image diagnostic techniques such as MRI and spiral CT. Then, radiofrequency heating is used to eliminate the addiction cells in the brain of drug addicted patients to achieve the purpose of treatment. The paper on this topic was published in the world’s leading neurosurgery journal, the American Journal of Stereotactic Functional Neurosurgery, and was a featured speaker at the quadrennial annual meeting of functional neurosurgeons in the United States. Mr. Zhang started to take psychoactive drugs seven years ago under the lure of his friends, and could not control himself; he became euphoric after taking the drugs, with no obvious withdrawal reaction, and repeatedly forced to quit under the supervision of his family, persisting for the longest 10 months, but finally failed; the amount of drug use gradually increased, and now he takes about 300-500 drugs per day, which seriously affects his work and life. Preliminary diagnosis: drug addiction Treatment history: After admission to the hospital, the examination and preoperative preparation were actively improved, and no absolute contraindication to surgery was seen in all tests. The patient volunteered for surgical detoxification, understood and accepted the possible risks and complications, and was treated with stereotactic intracerebral multi-target radiofrequency disruption under general anesthesia. The patient was discharged from the hospital with clear consciousness, good mental status, normal diet and sleep, normal urine and stool, normal body temperature, and no withdrawal symptoms. The head incision was healed A/Ⅰ and the stitches were removed. The patient did not have any complaints of discomfort and had good general activities. Discharge diagnosis: drug addiction Discharge medical advice: 1. Suggestions: pay attention to rest, reasonable nutrition. The patient was discharged from the hospital with a diagnosis of drug addiction. 2. Health education: Absolutely avoid re-exposure to various addictive drugs to prevent relapse. Quit smoking and drinking. Long-term family supervision and support.3. Follow-up time: 6 months, with follow-up for discomfort. The patient recovered well after surgery and did not have a need for drugs. After discharge, attention was paid to observing the patient’s condition and keeping abreast of his psychology, and a positive mood helped his physical recovery. During the return visit, we learned that Zhang had successfully quit drugs and no longer had any dependence. The phrase “cherish life and stay away from drugs” is a constant reminder that drugs are a bottomless pit, and once they are used, they can have a huge negative impact on the addict, his family and even society, and even kill him. “If you rely on your own willpower, it is almost impossible to be completely successful, and the dependence on drugs is lingering. Medical research has proven that drug addiction is essentially a recurring chronic brain disease. There are many effective clinical methods to eliminate physical dependence (detoxification), but “detoxification is easy and difficult”, and it is very difficult to eliminate psychological dependence (detoxification). Data show that the relapse rate of drug addicts is 85% within one month after detoxification, 95% within six months, and almost 100% for more than six months. If you have tried multiple methods of detoxification without success, surgical detoxification may be a last resort.