A female patient with significant pain on pressure on the right side of the lower abdomen is seen in the following conditions. First, patients with appendicitis. Appendicitis is located in the right lower abdomen, and the body projection corresponds to the site of the intersection of the external and external 1/3 of the line connecting the umbilicus and the anterior superior iliac spine. If the obstruction of a fecal stone leads to increased pressure in the appendiceal cavity, secondary infection and, in severe cases, septicemia, even complicated by restricted secretion. The patient may also experience significant right lower abdominal pain with fever, nausea, and vomiting. Prompt surgical treatment is required as an option. Second, adnexitis on the right side or ovarian cyst on the right side. This may also manifest as localized pressure pain and even palpable masses. Ultrasound examination can make a clear diagnosis. For inflammation, anti-infection treatment can be chosen, while ovarian cysts should be surgically removed at an elective stage, as they are also prone to torsion and require emergency surgery in severe cases.