Bilateral Bartholomew’s sign is an objective examination of the signs, not a name of the disease, clinically commonly used bilateral Bartholomew’s sign negative or positive to indicate that the negative represents normal, positive means that some parts of the lesions, common bilateral Bartholomew’s sign positive lesions are two aspects: first, cervical spondylosis, cervical spondylosis in the spinal cord type will be positive bilateral Bartholomew’s sign, for the reasons of this aspect, we can treat cervical spondylosis conservatively, surgically, and so on. We can treat cervical spondylosis either conservatively or surgically. Secondly, bilateral cerebral lesions or brainstem lesions, such as multiple cerebral infarcts, brainstem infarcts and so on. For this reason, we need to follow the principles of treatment of cerebral infarction, can use some drugs to improve cerebral circulation, the main thing is to control the risk factors that cause cerebral infarction, such as controlling blood pressure, blood glucose, blood lipids, but also to quit smoking, and at the same time also appropriate use of some of the antiplatelet aggregation of drugs, such as aspirin, clopidogrel, and so on.