Prolonged blood in stools accompanied by weight loss along with better appetite may be due to colitis, hemorrhoids, gastrointestinal tumors, and so on. It can be treated by drugs and surgery. 1. Colitis: patients mainly have diarrhea, abdominal pain, mucus stool, pus and blood stool, constipation and other abnormalities, often accompanied by weight loss and fatigue and other systemic manifestations. Some patients may have recurrent episodes. Amino salicylic acid preparations such as mesalazine can be taken as prescribed by the doctor, which is the main drug for the treatment of inflammatory bowel disease. 2. Hemorrhoids: Bleeding is the earliest symptom of hemorrhoids, manifested as blood in the stool paper, or blood on the surface of the feces, or blood dripping from the stool, bright red or even in the jet, which can be repeated episodes. Can follow the doctor’s instructions local use of topical drugs such as hemorrhoid cream, etc., to relieve hemorrhoids edema, pain and other effects. You can also use corkscrew, which can lubricate and stimulate the intestinal wall, soften the stool, and make it easy to be discharged. 3. Gastrointestinal tumor: tumor can easily cause gastrointestinal bleeding, if the tumor has not metastasized, surgical resection can be considered for treatment, if the tumor has metastasized, chemotherapy and other methods can be used for treatment. If the tumor has metastasized, it can be treated with chemotherapy and other methods. Chemotherapy drugs include oxaliplatin and so on. If the patient has blood in stool for a long time with lethargy and good appetite, he needs to go to the hospital in time, improve the relevant examination to clarify the cause of the disease, and take standardized methods of treatment, and use the drugs under the guidance of the doctor.