Helicobacter pylori infection can trigger thickening of the stomach wall in the sinus area, but thickening of the stomach wall in the sinus area is not necessarily caused by Helicobacter pylori infection. The most common cause of gastric sinus wall thickening is H. pylori infection. When H. pylori is infected, it triggers congestion and edema of the gastric mucosa, leading to thickening of the gastric wall of the gastric sinus. However, the presence of gastritis, gastric ulcer, gastric cancer and other diseases can also cause damage to the gastric mucosa, however, the regenerative capacity of the gastric mucosa is very strong, when the damage will be repaired by itself, in the process of repairing, it will cause the thickening of the gastric wall. In addition, the thickening of the gastric wall in the gastric sinus may also be related to gastric ulcer, gastritis, gastric cancer, and so on. In conclusion, if the thickening of the gastric wall in the gastric sinus occurs, it is recommended to consult a doctor in time, improve gastroscopy, 13C breath test and other tests to clarify the cause of the disease, and actively treat it to avoid delaying the condition.