SLE is an autoimmune disease characterized by autoantibody production and immune complex formation, and is also a common disease in rheumatology, with a prevalence of 70.4/100,000 in our country, and the lesions can involve all systems of the body. Due to its diverse manifestations, it is easy to be misdiagnosed or underdiagnosed clinically, and many patients do not receive active and effective treatment, thus missing the best time for treatment and delaying the disease, or even endangering their lives. The cause of the disease is still unclear, and it is generally believed that it may be the result of the joint participation of genetic, environmental factors, sex hormones and other factors. We have summarized the ten clinical manifestations of SLE, which should be highly alert to the occurrence of the disease if encountered clinically. 1. Recurrent skin erythema, especially facial pteroid erythema, and recurrent frostbite like lesions. These are easily ignored by patients or parents, especially the latter, and some diagnosed lupus patients often complain of a history of recurrent frostbite at a young age when consulted in the clinic. 2. Prolonged fever and malaise, especially if anti-infective treatment is ineffective. 3. Recurrent joint and muscle pain in the extremities in young female patients with negative rheumatoid factor. 4.Recurrent oral ulcers, erythema nodosum, depressed skin scars. 5.Recurrent whitening, purple and redness of the extremity endings, especially in the autumn and winter seasons or when exposed to cold air. 6.Unexplained hematological system injury, such as leukopenia, anemia, thrombocytopenia, etc. Bone marrow aspiration does not reveal obvious abnormalities. 7, young people without obvious risk factors (such as hypertension, hyperlipidemia, obesity, diabetes, etc.) appear cardiovascular disease. 8, digestive system manifestations, some persistent nausea, vomiting or abdominal pain, the conventional treatment effect is not good; or some abnormal elevation of liver enzymes (exclude viral infection and drug factors). 9, unexplained proteinuria, hematuria or renal insufficiency. 10.Recurrent spontaneous abortion, thrombosis of deep vein or stroke attack. Be highly alert to SLE in the above cases, and be sure to visit the Department of Rheumatology and Immunology to improve relevant examinations and make a clear diagnosis. There is no cure for lupus erythematosus, but timely and regular treatment can enable the disease to be better controlled and avoid or delay the damage of organs.