Both anti-dsDNA and anti-Sm antibodies are more specific antibodies for SLE and therefore have a high diagnostic value. More evidence suggests that anti-dsDNA antibodies (and their immune complexes) may have a direct pathogenic effect on the kidney, but the characteristics of anti-dsDNA antibodies that can cause lupus nephritis are so far unclear; cross-reactivity with endogenous antigens in the kidney is one possible mechanism, and effective deposition of immune complexes may also be important. Pathogenicity may also be related to the high affinity for DNA. High clinical levels of anti-dsDNA antibodies and low complement suggest a high risk of developing lupus nephritis. It has also been reported that anti-Sm antibodies may be associated with an increased incidence of Raynaud’s phenomenon and mild renal or CNS disease, but this has yet to be confirmed. For you, regular monitoring of urine-related tests and monitoring of renal function, along with attention to anti-dsDNA, anti-Sm antibody and complement levels, is an effective means of early detection of SLE-related renal damage.