EV71 vaccine is a targeted vaccine for hand, foot and mouth disease, and is to prevent any degree of hand, foot and mouth disease caused by EV71 infection. Adverse reactions include systemic reactions, mostly fever, local pain, redness, swelling, and hard nodules, and other rare adverse reactions that are treated symptomatically at the hospital according to the condition. This is related to the characteristics of the vaccine and the individual differences of the vaccine recipients. The age of vaccination for HFMD is from six months to five years old, and children should be vaccinated in a timely manner according to the situation.