Cephalosporin antibiotics, when combined with alcohol, can produce a disulfiram-like reaction. The disulfiram-like reaction refers to the inhibition of acetaldehyde dehydrogenase by disulfiram, which leads to the slow metabolism of ethanol in the body and the accumulation of a large amount of acetaldehyde, thus producing the corresponding toxicity. The more common clinical symptoms, is the emergence of a state similar to drunkenness, such as dizziness, nausea, vomiting, sometimes there may be certain hallucinations, and in serious cases, there may be a drop in blood pressure, shock, and even life-threatening. Therefore, during the taking of cephalosporins, alcohol consumption needs to be absolutely avoided. After taking Cephalosporin, patients may feel that their own alcohol consumption has become significantly smaller, and drinking a little alcohol produces a serious state of intoxication and disulfiram-like reactions, which may adversely affect the health of the organism.