The pain behind the earlobe is mostly caused by acute otitis externa, trigeminal postauricular neuralgia, etc. It can be treated with oral antibiotics and antiepileptic drugs according to different causes. 1. Acute otitis externa: mostly due to infection and skin trauma, etc., there will be pain behind the earlobe, burning sensation and other symptoms, can be oral amoxicillin and other antibiotics for treatment. 2. Neuralgia behind the trigeminal ear: patients can take drugs such as gabapentin, pregabalin and oxcarbazepine, because neuralgia is caused by abnormal local neuron discharge, and anti-epileptic drugs can effectively inhibit abnormal neuron discharge. Specific medication, it is recommended that patients under the guidance of the doctor, to avoid unauthorized use of medication to cause adverse effects.