Miconazole nitrate cream and ketoconazole are both antifungal drugs. Clinically there is no essential difference, miconazole nitrate belongs to imidazole antifungal drugs, ketoconazole belongs to pyrrole antifungal drugs. Miconazole nitrate cream and ketoconazole are broad-spectrum antifungal drugs, the two drugs are basically similar to the mechanism of action, by inhibiting fungal ergosterol biosynthesis and change the cell membrane of the other lipids chemicals, so as to achieve antifungal effect. Clinical therapeutic effect is not much difference, can treat fungal infection caused by ringworm, jock itch, tinea versicolor, tinea pedis and other diseases. The drug may cause skin irritation, causing tingling, burning, rash, etc., and is prohibited for those who are allergic to the drug. Precautions: avoid contact with eyes and other mucous membranes (such as mouth, nose, etc.). Use with caution in pregnant and lactating women. For the treatment of candidiasis, avoid sealing the bandage, otherwise it can promote the growth of pathogenic bacteria. Any burning sensation, redness or swelling at the site of application should be discontinued and the topical medication should be washed off, consult a physician if necessary. Children must be used under adult supervision. It is recommended that patients actively seek medical attention, follow the doctor’s instructions for standardized treatment, the drug needs to be used under the guidance of a professional doctor.