During the follicular phase of the normal menstrual cycle, the average serum testosterone concentration is 0.43 ng/ml, with a high limit of 0.68 ng/ml. If it exceeds 0.7 ng/m1 (equal to 2.44 nmol/L), it is called hypertestosteronemia, or hyperandrogenemia. The ovaries and adrenal cortex can synthesize cholesterol from acetic acid or absorb cholesterol from the blood as a substrate to synthesize steroid hormones, which are secreted into the blood circulation. The main androgens in the blood circulation are dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (Δ4A), testosterone (T) and dihydrotestosterone (DHT). Hypertestosteronemia is the result of high levels of these hormones, especially testosterone, in the blood. Diagnosis of significantly elevated serum testosterone concentration: 1. Hormonal changes in patients with significantly elevated serum testosterone concentration Excess androgens are the basic characteristics of patients with significantly elevated serum testosterone concentration. Patients with significantly elevated serum testosterone concentration may also have significant elevations of the following hormones, including testosterone, free testosterone, androstenedione, LH, LH/FSH ratio, free estradiol, estrone and fasting insulin. The diagnosis is based on the increase of blood testosterone >7.0ng/m1 or >2.44nmol/L. 2.B ultrasound examination for diagnosis The ratio of ovarian size to uterine size can be measured. An ovary larger than 1/4 of the uterine body or more can be considered as polycystic ovary. 3.Clomiphene treatment test Continuous administration of clomiphene for 3 cycles, if there is ovulation mostly for polycystic ovaries, if there is no ovulation in all 3 cycles, it can be considered as follicular membrane hyperplasia. 4.Posterior abdominal wall inflatable imaging The size and morphology of the adrenal glands can be examined to distinguish hyperplasia or hyperfunction of the adrenal cortex. 5.Laboratory hormone measurements Follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2) and testosterone (T) are measured by radioimmunoassay or enzymatic assay on the 9th day of menstrual cycle. high LH, high LH/FSH ratio and high T.