Infection with syphilis is usually not itchy. Itchiness can be caused by a number of allergic diseases, such as urticaria, atopic dermatitis, etc., as well as drug-induced rashes, and dry skin can also cause itching. Syphilis is a sexually transmitted disease that is categorized as Stage 1, Stage 2 and Stage 3 syphilis, with the common symptoms of Stage 1 syphilis being a hard chancre and swollen lymph nodes in the groin. The lesions of the chancre are characterized by cartilaginous ulcers on the genitals, which heal on their own at a later stage and do not itch throughout the course of the disease. Type 2 syphilis usually presents with a second-stage syphilis rash and flat warts, which are characterized by lesions with no fixed clinical features and no itching throughout the process. Some patients eventually form the third stage of syphilis, including cardiovascular syphilis, neurosyphilis, etc., and can even cause life-threatening, the whole process will not produce itching.