The causes of the whole glans tingling include glansitis, urethritis, genital herpes, etc., commonly used medication includes antibacterial drugs, glucocorticosteroids and so on. 1. glans: glans due to trauma after infection caused by inflammation will stimulate the head of the penis or the foreskin of the penis pain, different types of clinical manifestations are different, such as anaerobic infections will lead to edema of the foreskin as well as foul-smelling secretion, psoriasis caused by glans will appear red patches, and so on. For anaerobic infection, metronidazole is commonly used; for psoriasis infection, vitamin D is available; for allergic glans, hydrocortisone is available. 2. Urethritis: Urethritis is an acute and chronic inflammation caused by gonococcus or nongonococcus bacteria, and the main clinical symptoms include frequent urination, painful urination, redness and swelling of urethra. For gonococcal urethritis commonly used drugs include penicillin, ceftriaxone, etc., for non-gonococcal urethritis commonly used erythromycin, quinolones, metronidazole and so on. 3. Genital herpes: Genital herpes is a sexually transmitted disease caused by the herpes simplex virus. Herpes simplex virus infection can lead to blisters and ulcers in the genital area, often accompanied by pain and itching. Common medications include acyclovir and aspirin. The appropriate medication needs to be chosen under the guidance of a doctor. When patients experience discomfort, they should go to the hospital immediately.