Chronic apical inflammation refers to chronic periapical inflammation, when the nerve necrosis of the tooth need to take medication, root canal treatment. 1. Medication: If the patient has obvious inflammation, or the inflammation is spreading, the patient needs to use antibiotics, such as metronidazole, cefuroxime, ceftriaxone, etc., and non-steroidal anti-inflammatory pain relievers, such as ibuprofen, acetaminophen, etc., under the guidance of the doctor. However, they can only relieve the symptoms and cannot cure periapical infection. 2. Root canal treatment: For patients with chronic apical periodontitis with nerve necrosis, patients need to cooperate with the doctor to carry out root canal treatment to save the affected tooth, and secondly, they can also take the pulp blood flow reconstruction surgery, which can promote the continued development of the tooth root and regenerate the pulp. For those who do not get good results from root canal treatment, apical curettage or apicoectomy is needed. If in the acute stage, open pulp drainage is required. In conclusion, chronic apical periodontitis patients need to go to the hospital in time for standardized treatment, so as not to delay the condition, the use of drugs need to follow the doctor’s instructions.