Patient: Invasive ductal carcinoma grade III, Treatment: Breast tumor diagnosed on March 1, modified radical mastectomy for breast cancer on March 4. The patient was 62 years old. Postoperative pathology: right breast invasive ductal carcinoma, upper inner quadrant, maximum tumor diameter 3cm, lymph node metastasis 2/13. ER(++), PR(+), CerbB2(++), Ki-67(60% positive). What should I do now? Zhang Zhaohui, Department of Chemotherapy, Peking University Third Hospital, Beijing, China: The patient is 62 years old, with right-sided breast cancer, invasive ductal carcinoma in the upper inner quadrant, maximum tumor diameter 3cm, lymph node metastasis 2/13. If there is no other metastasis, the stage is T2N1M0, which is stage IIB and belongs to the middle stage. If the tumor is larger than 2cm and lymph node metastasis, it is a high risk factor and needs adjuvant chemotherapy. high KI-67 indicates high malignancy of the tumor, but also indicates sensitivity to chemotherapy. If positive, targeted therapy should be added, but if negative, it is not. Radiotherapy is recommended after adjuvant chemotherapy and endocrine therapy is required for 5 years. With standardized and aggressive treatment, the patient will have a best outcome. Breast cancer treatment is currently the most standardized and best among solid tumors, and the best outcome can only be achieved by actively following the standard. Family members need to be positive together with the patient in order for the patient to have a good outcome.