Antinuclear antibody positive joint pain may be caused by rheumatoid arthritis, systemic lupus erythematosus, dry syndrome, etc., which need to be treated with medication and surgery. 1. Rheumatoid arthritis: rheumatoid arthritis will have the symptom of joint pain, and the patient will have positive antinuclear antibody. Patients can use anti-rheumatic drugs such as Leflunomide under the guidance of the doctor. Some patients may also use non-steroidal anti-inflammatory drugs such as diclofenac sodium and indomethacin as prescribed by the doctor. For patients with joint deformity, surgery is needed to correct the deformity. 2. Systemic lupus erythematosus: patients with systemic lupus erythematosus will show joint pain and muscle weakness, and patients will be positive for antinuclear antibody when they undergo antinuclear antibody test. Patients need to follow the doctor’s instructions with prednisone acetate tablets, combined with immunosuppressive drugs, such as cyclophosphamide, azathioprine and so on. 3. Dry syndrome: patients with dry syndrome will have joint pain, and autoantibody test will show positive antinuclear antibody. For joint pain caused by dry syndrome, hydroxychloroquine and other non-steroidal anti-inflammatory drugs such as diclofenac can be used under the guidance of doctors. In addition, positive antinuclear antibodies accompanied by joint pain may also be certain tumors, etc. It is recommended that patients with positive antinuclear antibodies need to consult the Rheumatology and Immunology Department or other relevant departments in time to check the cause of the disease, and take appropriate measures for the cause of the disease to be treated.