High blood creatinine can lead to water, electrolyte and acid-base balance imbalance and systemic symptoms, such as hypertension, anemia, metabolic acidosis, calcium and phosphorus disorders. In severe cases, acute left heart failure, severe hyperkalemia, gastrointestinal bleeding, central nervous system disorders, etc., and even life-threatening. Creatinine is divided into endogenous creatinine and exogenous creatinine, exogenous creatinine is the metabolite of ingested meat, endogenous creatinine is the metabolite of creatine, which is produced in relation to the body’s muscular activities, and is excreted by the kidneys, with most of it filtered through the glomerulus and not reabsorbed by the tubules, and it is mainly used as an indicator to determine the degree of glomerular damage in clinical practice. High blood creatinine represents serious damage of renal function, and clinically, lack of appetite, vomiting, elevated blood pressure, left heart failure, cerebral edema, uremic cardiomyopathy, renal anemia, hemorrhagic tendency, severe hyperkalemia, gastrointestinal bleeding, and mental abnormality can occur. In serious cases, it is even life-threatening. People with high blood creatinine should seek medical treatment in regular hospitals in time and follow the doctor’s instructions to carry out standardized treatment, so as to avoid delaying the treatment and causing adverse consequences.