There is no prothrombin kinase time in medicine, the formal should be thromboplastin time, greater than 100 seconds may be congenital coagulation factor abnormality, acquired coagulation factor abnormality, blood anticoagulant status abnormality and other reasons. 1. Congenital coagulation factor abnormality: Generally, it is due to the abnormality of any one of the coagulation factors Ⅰ, Ⅱ, Ⅴ, Ⅶ, Ⅹ in the body, which will lead to the prolongation of prothrombin time. 2. Acquired coagulation factor abnormality: Generally, there are severe liver disease, vitamin K deficiency, hyperfibrinolysis, disseminated intravascular coagulation, etc. These factors will lead to coagulation factor deficiency and cause prolongation of prothrombin time, which can be alleviated by using vitamin K, vitamin K1 and other drugs. 3. Abnormal blood anticoagulation status: generally due to the presence of anticoagulant substances in the blood or the use of anticoagulant drugs, such as aspirin and other drugs, with anticoagulant effect, which will affect the coagulation mechanism, and then prolong the prothrombin time. Prothrombin time greater than 100 seconds need to go to the hospital in time to seek medical attention, under the guidance of medical advice for standardized treatment.