Bowen-like papulosis (“Bowen-like papulosis”) is closely related to human papillomavirus type 16 (HPV16), and HPV16 infection can be transmitted through sexual, direct or indirect contact. Various studies have shown that HPV antigenic structures and HPV16-associated gene sequences have been detected in skin lesions of patients with Bowen’s disease, suggesting that HPV16 infection is closely related to Bowen’s disease. HPV16 is mainly transmitted through close contact such as sexual intercourse, and is also associated with direct or indirect contact with the clothing and utensils of infected persons, all of which can easily lead to viral invasion, thus triggering the disease. Patients with Bowen-like papulosis are advised to go to the hospital for timely examination, and after a clear diagnosis, take surgical treatment, electrocautery treatment, laser treatment and other measures to remove the disease under the guidance of the doctor.