Hand, foot and mouth disease (HFMD) is an infectious disease illness caused by intestinal infections. Children with HFMD should be seen promptly and treated in isolation. Common treatment methods include general treatment, drug treatment, etc., specific should follow the doctor’s instructions. 1. General treatment: children with hand, foot and mouth disease, and appropriate isolation. For the child’s living things, need to use chlorine disinfectant soaking and boiling disinfection. For children with herpes in the oropharynx, a light liquid diet should be given to minimize pain. Avoid scratching the rash area to avoid skin breakage and infection. 2. Medication: For children with persistent high fever and encephalomyelitis and those in critical condition, glucocorticosteroids such as hydrocortisone and intravenous gammaglobulin can be used as appropriate. Generally, there is no need for special application of antiviral drugs. 3. Others: For children with fever caused by HFMD, increase the amount of water intake and use warm water baths to lower the temperature, and use antipyretic and analgesic drugs such as ibuprofen if necessary. Children with vomiting and diarrhea should be rehydrated to maintain electrolyte balance. Critically ill children can also be blood purification treatment. Parents should pay attention to children with hand-foot-mouth disease, bring children to the doctor in time, and actively cooperate with the doctor’s treatment. All of the above drugs should be used under the guidance of a doctor.