Amlodipine and nifedipine belong to the same class of antihypertensive drugs and are not recommended for simultaneous application. Both antihypertensive drugs belong to calcium antagonists, amlodipine is a long-acting calcium antagonist, which is effective in the treatment of hypertension and angina pectoris, and has a smooth blood concentration. Nifedipine, on the other hand, can be used for the prevention and treatment of angina pectoris, and is more effective in variant angina pectoris as well as angina pectoris with coronary artery spasm. Both drugs belong to the category of calcium channel blockers, and their combined use is not recommended. If you use the same class of drugs together, it will lead to excessive dosage of the drugs, and the superimposed antihypertensive effect will not be obvious, but the side effects will be increased, and there will be such adverse reactions as redness of the face, swelling of the lower limbs, gingival hyperplasia, and accelerated heart rate. It is contraindicated in women during pregnancy and lactation, as well as in patients with hypersensitivity to calcium antagonists. If the effect of one alone is not good, it is recommended to combine with other kinds of antihypertensive drugs, such as commonly used valsartan, Benadryl, metoprolol and so on. Clinical regulation of blood pressure is more complicated, and it is recommended to go to a specialized cardiology department for reasonable medication and treatment.