Patients with renal failure will develop skin lesions, most commonly caused by disorders of calcium and phosphorus metabolism, with low calcium and high phosphorus and high calcium and high phosphorus. If it is caused by low calcium and high phosphorus, it can be treated with oral calcium carbonate; if it is caused by high calcium and high phosphorus, it can be treated with oral sevelamer and other drugs, while intravenous sodium thiosulfate can be infused to relieve the symptoms. Some patients who are still not effective through the above treatments can be treated by renal replacement therapy, such as enhanced hemodialysis, hemofiltration, hemodialysis filtration, etc. There are also patients who do not have disorders of calcium and phosphorus metabolism and have generalized pruritus, mainly due to advanced chronic renal failure, poor nutritional status and low immune function, which can lead to secondary skin changes, such as pruritus. In such cases, it is recommended that patients actively strengthen nutritional support therapy and eat more high-quality protein to promote the improvement of the disease, and also apply topical drugs, such as trimethoprim cream to relieve.