Blood tests are not sufficient to confirm the diagnosis of bone tuberculosis, which is based on history, signs, symptoms, laboratory and imaging tests. Patients with bone tuberculosis may have mild anemia on routine blood tests, and the white blood cell count is usually normal, with a few patients having elevated white blood cells, but this is not enough to confirm the diagnosis of Mycobacterium tuberculosis infection. Blood sedimentation can be used to detect whether the lesion is static or recurrent, and C-reactive protein can be used to diagnose tuberculosis activity and clinical efficacy, but abnormalities in blood sedimentation and C-reactive protein are also not enough to confirm the diagnosis of bone tuberculosis. The diagnosis of bone tuberculosis needs to be made by combining the history, signs, symptoms, laboratory and imaging tests, and differentiating from diseases with similar manifestations of bone tuberculosis, such as septic osteoarthritis, so as to confirm the diagnosis of bone tuberculosis. If a patient has symptoms or abnormal blood tests, he or she should go to the hospital in time to complete the relevant examinations, make a clear diagnosis and standardize the treatment.