If you don’t want to take metformin, you can use other types of hypoglycemic drugs instead, such as DPP-4 inhibitors, SGLT-2 inhibitors, α-glucosidase inhibitors, etc. It is recommended to use drugs under the guidance of a doctor. Metformin belongs to the biguanide class of hypoglycemic drugs, which is the first line of medication for controlling blood glucose in type 2 diabetes mellitus, and other types of hypoglycemic drugs can be considered if there is a need to replace the medication, such as obvious adverse reactions after taking the medication. 1. DPP-4 inhibitors: also known as dipeptidyl peptidase 4 inhibitors, can inhibit glucagon-like peptide-1 (GLP-1), increase endogenous GLP-1 and GLP, and promote the release of insulin from insulin B-cells, which in turn can lower blood glucose. Such drugs include selegiline, vigliptin, saxagliptin and so on. 2. SGLT-2 inhibitors: also known as sodium-glucose cotransporter 2 (SGLT-2) inhibitors, including dagliflozin, empagliflozin, cagliflozin and so on. They can reabsorb glucose in the glomerulus, lower the renal glucose threshold, promote the urinary excretion of glucose, and then play a role in lowering glucose. 3. α-glucosidase inhibitors: can inhibit the α-glucosidase of the small intestinal mucosa, and then delay the absorption of glucose, reduce postprandial blood glucose. Such drugs are acarbose, voglibose and so on. Patients who do not want to take Metformin are advised to visit the hospital and ask the doctor to make a judgment on whether they need to change to other medication.