The symptoms of generalized numbness on the second day after drunkenness may be physiological, such as caused by excessive alcohol intake stimulating the capillaries, and may also be caused by peripheral circulatory abnormalities, peripheral nerve injury, cerebrovascular disease and other pathological factors. 1. Physiological factors: drinking too much alcohol at one time, resulting in excessive ethanol intake, ethanol into the bloodstream leading to rapid expansion of capillaries, which in turn causes microcirculation expansion, resulting in generalized numbness. 2. Pathologic causes: (1) Abnormal peripheral circulation: ethanol into the blood leads to rapid expansion of capillaries, blood pressure can be lowered at the same time, causing abnormal peripheral circulation, resulting in generalized numbness. (2) Peripheral nerve damage: ethanol has certain damage to peripheral nerves, especially in patients who drink frequently, which can cause peripheral nerve damage, resulting in numbness of the limbs or even the whole body. (3) Cerebrovascular disease: Cerebrovascular diseases such as cerebral blood supply insufficiency and cerebral infarction are prone to numbness of the limbs and other sensations, and the symptoms are more obvious after drinking. The numbness of the whole body after drunkenness is very strong, it is recommended that the patient quit drinking, and if physiological factors are excluded, it is recommended to consult a doctor as soon as possible to find out the cause.