Although I’ve written a lot of this science in the science, I still keep getting inquiries about what to do with low progesterone, so it seems that I need a series of science. First of all, I would like to make a popularization to the obstetricians and gynecologists that it is not necessary to conduct beta hCG and progesterone tests for all pregnant women in early pregnancy. I don’t know when beta hCG and progesterone testing became common in China. beta hCG and progesterone testing is useful for differential diagnosis and prognosis of pregnancy in patients with irregular vaginal bleeding in early pregnancy, but it is a bit excessive to test every pregnant woman. Many pregnant women are diagnosed as having “low progesterone” and are then given oral progesterone or progesterone to “protect the fetus”. The medical measures seem to sound reasonable, low, prone to miscarriage, so to be supplemented, pregnant women heard, the baby is important, then take drugs and injections it. However, is such a measure in fact reasonable?” There is no evidence to support progestin preservation therapy for such cases, which is the result of a large global sample of studies and the recommendation of the World Health Organization. Most miscarriages in early pregnancy are related to the genetics of the embryo, and most miscarriages occur because the child cannot continue to grow and is eliminated, the incidence of which is about 7.5% in the population, and low progesterone in such cases is also a consequence, but not the cause of the miscarriage. Progesterone supplementation for fetal preservation is not beneficial, and the current findings support progesterone treatment for pregnant women with a history of more than 3 miscarriages. If there is vaginal bleeding during early pregnancy, beta hCG and progesterone tests are helpful to help the doctor to make diagnosis and differential diagnosis. A single progesterone result can help to determine the prognosis, usually in good intrauterine pregnancy, the progesterone result will be above 25 ng/ml, while a progesterone result <5 ng/ml is indicative of poor pregnancy outcome, between 5 and 25 ng/ml means that the outcome is unknown and needs to be further understood. Therefore, such a progesterone result cannot be used as an indication for progestational intervention, but it is useful for clinicians to determine the prognosis or differential diagnosis. In conclusion, it is emphasized that one: it is not necessary to test progesterone in every pregnant woman; and two: it is not necessary to come to progesterone supplementation even if the test is low.