Compared with vitamin B12, methylcobalamin has better efficacy.1. Methylcobalamin belongs to endogenous vitamin B12, which can promote the synthesis of lecithin in patients’ tissues after being absorbed into the blood, and promote the recovery of neuronal demyelination. Therefore, it can nourish the peripheral nerves of patients and improve the symptoms of limb numbness, and the utilization rate and absorption rate of the drug are relatively high. 2. Vitamin B12 cannot be manufactured by higher animals and plants themselves, it is a synthetic substance and needs to be absorbed with the help of secretions and endogenous factors in the intestine, and the time it stays in the intestine is about 3 hours. Therefore, its effect is not as good as that of methylcobalamin because it needs to be degraded after being absorbed.