When H. pylori treatment becomes resistant, drug sensitivity test is recommended to change the relatively sensitive antibiotic for treatment. Currently, H. pylori infection is mainly treated with quadruple therapy, i.e., proton pump inhibitor such as omeprazole plus bismuth agent such as bismuth potassium citrate plus two antibiotics such as amoxicillin and clarithromycin. Drug resistance of H. pylori is the most important reason for eradication failure, after the failure of eradication, you can choose antibiotics with relatively low resistance rate such as amoxicillin, tetracycline for treatment or change antibiotics according to the results of drug sensitivity test for secondary eradication. During the period of treatment, you should strictly follow the doctor’s instructions to take the antibiotics on time and in accordance with the dosage, and follow the doctor’s instructions for timely review after the end of the treatment.