Bile reflux pain in the upper abdomen after cholecystectomy may be due to wound infection, bile reflux and costochondritis. 1. wound infection: patients after cholecystectomy surgery will form a wound in the upper abdomen, patients in the postoperative physical inappropriate may lead to wound infection and inflammation, resulting in epigastric pain. 2. Bile reflux: Bile reflux can cause burning and pain in the upper abdomen, which is mainly due to the reflux of bile into the digestive tract, causing damage to the digestive tract. 3. Costochondritis: After cholecystectomy, the incision may cause costochondritis, which may lead to epigastric pain. It is recommended that patients who experience discomfort after surgery should seek timely medical examination and treatment to avoid aggravation of the condition.