Mucosal hyperplasia in esophagus may be caused by precancerous lesion of esophagus, reflux esophagitis, gastritis and so on. 1. Pre-cancerous lesion of esophagus: Pre-cancerous lesion of esophagus refers to the abnormal proliferation of normal cells of esophageal cancer, which is a transitional stage of developing into cancer cells. Initial symptoms are usually not obvious, mainly manifested as foreign body sensation when swallowing, phlegm, and esophageal mucosal chemosis can be seen in biopsy pathology. 2. Reflux esophagitis: Reflux esophagitis is generally caused by the decrease of patients’ anti-reflux ability. If there is damage to the esophageal mucosa, it may cause esophageal erosion or ulceration, and bile and gastric secretion will back up into the esophagus, which will lead to mucosal metaplasia in the esophagus, and at the same time, there will also be heartburn and other symptoms. 3. Gastritis: Gastritis is a relatively common digestive system diseases, can be accompanied by Helicobacter pylori infection, due to long-term damage to the gastric mucosa, may lead to superficial gastritis or chronic gastritis, usually belching, acid reflux, abdominal distension and other symptoms, can be accompanied by esophageal mucous membrane growth. It is recommended that patients go to the hospital in a timely manner, after clarifying the cause of the disease under the guidance of the doctor for standardized treatment.