Atenolol and betaxolol are both beta-blockers and are useful in controlling heart rate, lowering blood pressure, and improving ventricular remodeling. However, there are some differences between the two. Atenolol is mainly water-soluble and does not cross the blood-brain barrier, which may have some advantages in terms of adverse effects, such as not being prone to cause depression in patients and impotence in male patients. Betaxolol, on the other hand, is a fat-soluble and tends to pass the blood-brain barrier, which may cause poor mood in patients and even impotence in male patients, etc. Metoprolol is metabolized through the liver and can be applied for patients with renal insufficiency. Atenolol, on the other hand, is mainly excreted through protoplasmic urine and is not recommended for patients with severe renal insufficiency. The bioavailability of atenolol is long, with a half-life between 6-7 hours, which can easily cause accumulation in the body, so it is not recommended for patients with renal insufficiency. Metoprolol, on the other hand, has a relatively short half-life of about 3-5 hours, and it may be that for this condition, metoprolol should be administered more frequently and is recommended twice daily, although there are currently extended-release tablets that can be applied once/day.