Lumbosacral to gluteal pain should be treated according to the cause, and common causes include physiological causes, as well as pathologic causes such as lumbosacral myofasciitis, lumbar disc herniation, sacroiliac arthritis, and so on. Treatment methods include general treatment, drug treatment, physical therapy, surgical treatment and so on. 1. Physiological causes: If long time bending and heavy physical activity or improper exercise cause lumbosacral and buttock muscle strain, it can be manifested as lumbosacral and buttock pain, usually without other accompanying symptoms, and can be relieved by rest. 2. Lumbosacral myofasciitis: generally caused by exertion, trauma, can be manifested as pain in the area, rest does not relieve, available non-steroidal anti-inflammatory drugs such as diclofenac sodium, etc. to relieve the pain, but also physical therapy such as heat, acupuncture, massage, etc.. 3. Lumbar disc herniation: Lumbar disc herniation can compress the nerves, causing pain in the lumbosacral region and buttocks, accompanied by numbness of the lower limbs and other symptoms. It is necessary to pay attention to rest, avoid bending, take non-steroidal anti-inflammatory drugs such as ibuprofen to relieve pain symptoms, with traction, physical therapy, etc. If conservative treatment is ineffective, surgical treatment such as nucleus pulposus removal of the intervertebral disc. 4. Sacroiliac arthritis: It can be manifested as pain in the lumbosacral region and buttocks, which will be aggravated after activities, and can be caused by infection, ankylosing spondylitis, and bad posture. Non-steroidal anti-inflammatory drug Celecoxib can be taken to relieve the pain, and at the same time with physical therapy, followed by the treatment of the cause, such as ankylosing spondylitis. Lumbosacral to buttock pain can also be seen in other causes, exclude the physiological causes, and then go to the hospital in time, clear cause diagnosis, timely treatment. All of the above drugs should be used under the guidance of a doctor.