Taking atorvastatin for calf pain is severe and should be treated promptly. Atorvastatin is a commonly used anti-atherosclerotic plaque as well as lipid-lowering drug, but it has many side effects. Once side effects arise such as calf pain, whether serious or not, you should go to the hospital for consultation and treatment, and follow the doctor’s instructions to stop the drug or do other treatments. Muscle soreness caused by atorvastatin is usually symmetrically distributed, predominantly in both calves, and can be persistent in nature. The diagnosis can be made with a history of drug use and by ruling out other causes such as trauma or infection. Muscle soreness is due to the lysing effect of atorvastatin on the rhabdomyocytes, causing their destruction. If left unchecked, it can cause extensive rhabdomyolysis, which can throw electrolytes out of balance and cause serious, life-threatening damage to the heart and other organs. Atorvastatin can also cause damage to liver function such as elevated aminotransferases and kidney function such as proteinuria. Therefore, patients with poor liver and kidney function are prohibited from taking this drug, and also need to be carefully paired with amlodipine and strictly control the dose to avoid adverse reactions. If you need to use the drug, please follow the doctor’s instructions.