Liver nodule 1cm growing to 2cm in four years is very serious. At present, the patient’s liver nodule has grown from 1cm to 2cm in four years, and the liver nodule has obviously increased in size, which does not exclude the possibility of hepatocellular carcinoma, and it is necessary to carry out liver puncture biopsy examination, and if it is determined that it is hepatocellular carcinoma, then it is necessary to carry out surgical treatment to remove the liver nodule. If the diameter of liver nodule is more than 10mm, we need to be more vigilant, because the liver nodule starts to be serious, and we need to have regular review of liver ultrasound or CT examination to see if the diameter of liver nodule is increasing, whether there is any compression of the surrounding tissues and structures, and if the imaging or ultrasound examination describes the hypoechoic changes of liver nodule, we need to be vigilant about the risk of liver cancer. Patients with liver nodules should go to the hospital if they have any discomfort, and should not be careless so as not to delay the treatment.