A patient was stung by a mosquito causing a bacterial infection of the skin of the lower extremities, the dermatologist suggested that oral antibiotics were needed while strengthening local disinfectant care, suggesting that amoxicillin clavulanate potassium (penicillin) could be used for anti-infective treatment. At this point, the patient asked rhetorically, “I have a history of systemic lupus erythematosus, are penicillins not suitable for use?” Lupus patients, penicillin class of drugs actually can not be used? 1, drug lupus drug lupus that is drug-induced lupus, refers to the taking of certain drugs caused by arthralgia, rash, fever, plasma membrane inflammation, anti-nuclear antibodies (ANA) in the blood, anti-histone antibodies of a clinical syndrome. So, let’s see which drugs are associated with drug lupus? Drugs that have been shown to be definitively associated with pharmacologic lupus include: procainamide, hydralazine, minocycline, diltiazem, penicillamine, isoniazid (INH), quinidine, anti-tumor necrosis factor-alpha (TNF-alpha) treatments (usually referred to as infliximab and etanercept), interferon, methyldopa, chlorpromazine, and cardioplegia. Drugs that have been clinically observed to be most likely associated with pharmacologic lupus include anticonvulsants (e.g., phenytoin, mefenamic acid, trimethoprim, ethosuximide, carbamazepine), antithyroid medications, antimicrobials (sulfasalazine, rifampicin, furosemide), β-blockers, lithium, para-aminosalicylate, captopril, gamma-interferon, hydrochlorothiazide, glibenclamide, lorazosulfamethiazole, terbinafine, amiodarone, and other medications that may be associated with pharmacologic lupus. terbinafine, amiodarone, ticlopidine, and docetaxel. Clinical observations suggest that drugs that may be associated with drug-induced lupus include: gold, penicillin, tetracycline, reserpine, valproate, statins (e.g., lovastatin, simvastatin, and atorvastatin), pallidomycin, xylomethylheptanoic acid, valproate, lamotrigine, and aminosalicylic acid, among others. 2, penicillin can be used in lupus patients or not? We can see that penicillin is really inside the drugs that clinical observation thinks may be associated with medicated lupus, so, can penicillin be used in lupus patients or not? As a matter of fact, the pathogenesis of drug-induced lupus is not exactly the same as that of primary lupus. Therefore, in principle, this kind of drugs that may induce drug lupus is not a contraindication for patients with primary lupus, and can still be used when clinically judged to be necessary. It is only necessary to strengthen the observation when applying them. In addition, drug-induced lupus is often milder than primary lupus, and clinical symptoms tend to resolve rapidly after stopping the drug, so we are not so worried. Therefore, most patients in the clinic have heard that lupus patients should not use penicillin drugs because it will aggravate the condition of lupus, and the result of the blackmail is that everyone ends up believing it, and even clinicians feel that this is the case. Penicillins are allergy-prone medications However, penicillins are allergy-prone medications, and it is important to check if you have ever used penicillins and have a history of allergy before using them. If you have not used penicillins before, you also need a negative skin test before use. Because once severe allergy occurs, immune over-activation, the lupus condition will have adverse effects.