It is possible for a gallbladder with a less-than-smooth wall to heal on its own. Depending on the cause, the possibility of self-healing varies. The main cause of gallbladder wall irregularities is the lack of attention to daily life, such as overeating, stress, and nervousness. It is possible to regulate the diet, refrain from overeating, stop smoking and drinking, release stress, and adjust lifestyle habits, in which case it is possible to recover from gallbladder wall opacification. If the wall of the gallbladder is not smooth because of some diseases, such as gallbladder stones or bile stasis, biliary tract infection and other factors, usually there is no way to heal by itself. In this case, it is advisable to seek immediate medical attention so that the doctor can determine the course of treatment.