You should not take ibuprofen for a headache after drinking alcohol. The ethanol in alcohol will gather in the body and cause the blood vessels to dilate, so many people will have a headache, which will gradually improve after the alcohol is metabolized. In principle, all drugs should not be taken after drinking alcohol, as this will not only affect the effect of the drug, but also some of them will react with alcohol, which will have an impact on human health. Ibuprofen itself is an anti-inflammatory drug that can cause side effects after taking it, the common ones being nausea and vomiting. Although taking ibuprofen after drinking can help relieve headaches, it can cause some damage to the digestive system and also aggravate the loss of liver function. Alcohol is basically metabolized by the body about 24 hours after drinking, when the headache still exists, you can take ibuprofen to relieve it properly.