If the appendix becomes inflamed, it should be treated with timely anti-inflammatory and anti-inflammatory therapy. Mild cases can be treated with oral anti-inflammatory drugs, commonly used are roxithromycin dispersible tablets, or oral penicillin V potassium tablets and amoxicillin capsules, and the changes in abdominal symptoms as well as signs should also be observed during treatment. Acute simple appendicitis with significant abdominal pain and fever can also be treated early with intravenous anti-infective therapy. Cephalosporin or penicillin sodium is usually administered intravenously and needs to be combined with metronidazole, especially in adults, and fluid should also be appropriately supplemented during treatment. If the patient’s condition gradually worsens and the symptoms do not improve with conservative treatment, further surgical treatment is required if necessary. This is because appendicitis also includes suppurative appendicitis, gangrenous appendicitis, and even severe periappendiceal abscesses. Conservative treatment for these types of appendicitis is not effective and the most effective option is surgery to remove the appendix.