Autoimmune hepatitis AIH is a substantial inflammation of the liver mediated by an autoimmune response against the hepatocytes themselves, which manifests clinically as positive autoantibodies, hyper-IgGemia and gamma-globulinemia, and on liver histology as interface hepatitis. Autoimmune hepatitis is a more serious and complex liver disease, which often leads to cirrhosis and even liver failure if not treated properly. AIH can manifest clinically as a chronic process, and some patients have an acute, fulminant process. some data show that about 30% of patients are already cirrhotic by the time they are found to have AIH, and all patients with AIH About 1-2% of all AIH patients will develop into hepatocellular carcinoma, so it is a more serious and complicated liver disease.