The effect of cephalosporin on kidney function is relatively small. Cephalosporin is a class of antibiotics often used in clinical practice, and penicillin is considered a large class of drugs, this drug does not have much effect on the kidneys, therefore, patients with kidney disease can consider applying cephalosporin antibiotics after concurrent infections, such as lung infections, urinary tract infections, gastrointestinal infections, etc. Cephalosporin antibiotics belong to a broad-spectrum class of antibiotics, that is, they are effective for most bacteria, and therefore, can kill most bacteria. However, it should be emphasized that cephalosporins are divided into several generations. The first and second generations have some effects on the kidneys, while the third and fourth generations have less effect on the kidneys and have a stronger ability to kill bacteria. Therefore, when choosing cephalosporin antibiotics, try to use the third and fourth generation.