The usage of hormones includes systemic application (intravenous and oral) and local application (local skin topical application, joint cavity injection, intraocular injection, etc.). Depending on the needs of the condition, hormones can be given either as a morning dose, every other day or in daily doses. Hormones can be divided into 4 dose ranges: small dose: prednisone ≤7.5mg/d (methylprednisolone ≤6mg/d); medium dose: prednisone 7.5-30mg/d (methylprednisolone 6-24mg/d); large dose: prednisone 30-100mg/d (methylprednisolone >24-80mg/d); shock therapy: methylprednisolone 500-1000mg/d. The higher the dose of hormone, the more effective it is, but also the greater the side effects. Hormone is like a double-edged sword, how to pursue the efficacy while minimizing the side effects of hormone is one of the most important concerns of clinicians.