Taking cyclosporine for 4 months for membranous nephropathy is usually not discontinued unless there are serious side effects. Cyclosporine is a kind of immunosuppressant for the treatment of idiopathic membranous nephropathy, and the guideline suggests that it should be discontinued if partial remission is not achieved after 6 months of treatment; if complete or partial remission is achieved and no serious nephrotoxicity occurs, it is suggested that cyclosporine should be reduced to 50% of the initial dosage in 4-8 weeks, and the full course of treatment should be at least 12 months. Therefore, 4 months of treatment generally can not stop the drug, even if at this time the disappearance of urinary protein, renal function is normal, edema disappeared, but also can not stop the drug, in order to avoid the recurrence of the disease. However, if the patients have serious adverse reactions of cyclosporine, they need to reduce the dosage or even stop the drug, such as rapid decline in renal function, uncontrollable hypertension, uncontrolled infections, as well as the emergence of malignant tumors or abnormal proliferation of lymphoid tissues and so on. The use of cyclosporine in patients with membranous nephropathy should be under the guidance of a professional physician, and should not reduce the dosage on its own, not to mention stopping the drug on its own.