In general, systemic chemotherapy is administered intravenously, intramuscularly or orally. However, in some cases, changing the route of administration can increase the intensity of local tumor killing and reduce the adverse effects on the whole body. (1) Intracavitary injection: including thoracic, pericardial and intraperitoneal chemotherapy, commonly used drugs include: cisplatin, carboplatin, mitomycin, cetiapide, etc. (2) Arterial cannulation chemotherapy: In order to improve the local drug concentration, arterial intervention can be used for confined tumors, such as hepatic artery intervention for liver cancer and external carotid artery cannulation for head and neck cancer. (3) Intrathecal injection: It is often used to treat meningeal leukemia or lymphoma, or metastasis within the central nervous system of other solid tumors, or the antitumor drugs can be injected directly into the cerebrospinal fluid. (4) Local injection: Anti-tumor drugs are injected directly into the tumor, which is often used in the local treatment of superficial tumors and palliative treatment of liver cancer and lung cancer.