Pre-depression in the choice of medication is still based on antidepressant drug systemic therapy. For patients with depression, especially the application of 5-hydroxytryptamine reuptake inhibitors is the first line of clinical drugs, such as the application of paroxetine, sertraline, fluoxetine, escitalopram, venlafaxine and other drugs can achieve good therapeutic effect. Through the application of such drugs can improve the balance of 5-hydroxytryptamine in the patient’s body to treat the manifestation of depression. Depression is characterized by low mood, slow thinking, and reduced volitional activity. By applying this type of 5-hydroxytryptamine inhibitor drugs can adjust the balance of 5-hydroxytryptamine in the brain, and eventually treat the corresponding symptoms. In addition, psychotherapy can also be used as an effective treatment method, mainly cognitive behavioral therapy to improve the patient’s irrational cognition, to achieve the role of cognitive reconstruction. Therefore, the systematic and standardized treatment of the whole course of the disease is still a very important part of the whole course of treatment of depression.