Patient: Hello doctor, the ulcer in the duodenal bulb has bled twice, why does it always come back after stopping the medication, and the recurrence is often accompanied by bleeding (black stool)! Can there be any good way to get rid of it? I have been treating it with quadruple therapy, but after stopping the medication, it will come back and bleed. Zhang Xinjun, Department of Gastroenterology, Affiliated Hospital of Ningbo University Medical College: 1, look for the cause, such as HP infection, some drugs that damage the gastric mucosa intake (such as aspirin, non-steroidal anti-inflammatory drugs have a direct role in destroying the gastric mucosa), bile reflux, alcohol, decreased ability to renew the gastric mucosa (such as anemia, malnutrition, etc.), smoking and strong tea and coffee and other stimuli, mental tension and anxiety, symptomatic treatment; 2, regular Take medication; 3. Regularly review gastroscopy.