Most cold and flu medicines are usually okay to take with atorvastatin, but there are some medicines for cold and flu that are not okay to take with atorvastatin, such as clarithromycin and erythromycin. Atorvastatin is a cardiovascular drug that is mainly used to treat hypercholesterolemia. This drug can usually be taken with most cold medicines, but not with macrolide antibiotics that have the effect of treating colds, such as clarithromycin and erythromycin, so as not to affect the metabolism of the drug. In addition, atorvastatin may cause gastrointestinal discomfort as well as adverse reactions such as headache, rash, and dizziness after taking it. If patients experience serious discomfort after taking the drug they need to seek prompt medical attention. Atorvastatin is contraindicated in patients with active liver disease, those who are allergic to any of the ingredients in the product, pregnant and lactating women. Since atorvastatin is a prescription drug, it is necessary to follow the doctor’s instructions.