The best time to take a statin at night is between eight and ten o’clock, and the newer statins can be taken at any time throughout the day. Statins are used to treat conditions such as hypercholesterolemia, and for lipid-lowering drugs such as simvastatin and pravastatin, it is best to take them orally at night. Lipid synthesizing enzymes are most active at night. Taking lipid-lowering drugs at night, with higher blood concentration, can better inhibit cholesterol synthesizing enzymes and play a role in lowering cholesterol. Newer lipid-lowering drugs such as atorvastatin calcium are long-acting drugs that can be taken at any time of the day to lower cholesterol and do not need to be taken orally at night. Adverse effects such as abdominal pain, constipation and fever may occur after taking statins. Patients with active liver disease and pregnant women should avoid using this drug. In the process of taking statin lipid-lowering drugs, we should pay attention to understand the characteristics of the action of the drug, according to the characteristics of the drug to choose the appropriate time to take the drug, and use the drug under the guidance of the physician, to better play the role of lipid-lowering drugs.